SHCBP1 — SHC binding and spindle associated 1
SHCBP1 belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
SHCBP1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | Mitotic Spindle Cell cycle | CENPF, GTSE1, HMMR, KIF11, KIF22, KIFC1, NCAPG, SGO1 +3 more | View in SCUBA |
| CD8⁺ T cells | Mitotic Spindle Assembly Cell cycle | FBXO5, LRR1, MELK, MTFR2, NCAPG2, RAD51AP1, SKA1, SKA3 +3 more | View in SCUBA |
| Goblet cells | FOXM1-driven G2/M Cell cycle | CDCA5, CENPK, DIAPH3, E2F8, ESCO2, FOXM1, IQGAP3, MELK +5 more | View in SCUBA |
| Macrophages | S-phase DNA Replication Cell cycle | ATAD2, ATAD5, BARD1, BRCA1, CENPK, CENPM, CENPU, CLSPN +31 more | View in SCUBA |
About the gene
| Synonyms | FLJ22009, PAL |
|---|---|
| Chromosome | 16: 46578591-46621379 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
Function
May play a role in signaling pathways governing cellular proliferation, cell growth and differentiation. May be a component of a novel signaling pathway downstream of Shc. Acts as a positive regulator of FGF signaling in neural progenitor cells
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.