Mitotic Spindle Assembly
Gene co-expression module in CD8⁺ T cells
| Category | Cell cycle |
|---|---|
| Genes | 12 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 12 of 12 genes have a known function matching the annotation |
Why this annotation
All 12 genes are canonical mitotic cell cycle regulators. MELK is a mitosis-promoting kinase; FBXO5 (Emi1) inhibits APC/C to allow S/G2 entry; SPC25 and SPC24 are kinetochore components of the Ndc80 complex; UBE2T is a ubiquitin-conjugating enzyme required for DNA repair and mitosis; SKA1/SKA3 form the Ska complex required for kinetochore-microtubule attachment and chromosome segregation; SHCBP1 functions during cytokinesis; MTFR2 promotes S-phase entry; RAD51AP1 supports homologous recombination; NCAPG2 is a condensin II subunit; LRR1 regulates cell cycle progression. Uniform low expression (~3.7% positive) indicates this module marks a rare proliferating CD8 T cell subpopulation. Neighboring modules (M15, M77, M84, M55, M75, M38) all encode cell cycle programs, confirming a tight proliferation neighborhood in the network.
Genes
FBXO5, LRR1, MELK, MTFR2, NCAPG2, RAD51AP1, SHCBP1, SKA1, SKA3, SPC24, SPC25, UBE2T
Most correlated modules
- FOXM1-driven G2/M · correlation 0.98
- Mitotic Spindle · correlation 0.97
- G2/M Checkpoint · correlation 0.97
- CDK1-Aurora Kinase Mitosis · correlation 0.96
- Mitosis & Cytokinesis · correlation 0.95
- Spindle Bipolarity Cytokinesis · correlation 0.93
- Replication Licensing · correlation 0.93
- S-phase Chromatin Replication · correlation 0.92
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.