MARF1 — Meiosis regulator and mRNA stability factor 1
MARF1 belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
MARF1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | Chromatin & genome maintenance DNA/chromatin regulation | ARID1B, ASH1L, ATM, ATRX, BOD1L1, DDX17, KANSL1, NKTR +8 more | View in SCUBA |
About the gene
| Synonyms | KIAA0430, LKAP, LMKB, PPP1R34 |
|---|---|
| Chromosome | 16: 15594387-15643154 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
| Molecular function | RNA-binding |
| Biological process | Differentiation, Meiosis, Oogenesis |
Function
Essential regulator of oogenesis required for female meiotic progression to repress transposable elements and preventing their mobilization, which is essential for the germline integrity. Probably acts via some RNA metabolic process, equivalent to the piRNA system in males, which mediates the repression of transposable elements during meiosis by forming complexes composed of RNAs and governs the methylation and subsequent repression of transposons. Also required to protect from DNA double-strand breaks (By similarity)
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.