Chromatin & genome maintenance
Gene co-expression module in CD19⁺ B cells
| Category | DNA/chromatin regulation |
|---|---|
| Genes | 17 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 8 of 17 genes have a known function matching the annotation |
Why this annotation
Hub genes are overwhelmingly chromatin and genome-maintenance regulators: KANSL1 (NSL complex/H4K16ac), ASH1L (H3K36 methyltransferase), ATRX (chromatin remodeler), SETD2 (H3K36me3), ARID1B (BAF complex), ATM (DNA damage), BOD1L1 (fork protection), SETX (R-loop resolution), plus RNA regulators DDX17, TUT4, MARF1. This is a clear DNA/chromatin regulation and genome maintenance module.
Genes
ARID1B, ASH1L, ATM, ATRX, BOD1L1, DDX17, KANSL1, MARF1, NKTR, OGA, PHKB, SETD2, SETX, TTC14, TUT4, ZNF292, ZNF791
Most correlated modules
- Chromatin modifiers · correlation 0.90
- B-cell signaling regulators · correlation 0.89
- mRNA splicing · correlation 0.85
- Lymphoid signaling regulators · correlation 0.84
- B-cell antigen presentation · correlation 0.76
- Chromatin Modification · correlation 0.74
- BCR signaling/maturation · correlation 0.74
- B-cell signaling regulators · correlation 0.70
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.