MEP1B — Meprin A subunit beta
MEP1B belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
MEP1B's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Enterocytes | Villus-tip enterocyte transport Absorption | ABCG2, AQP3, AQP7, BEND7, C2orf88, CDKN2B, MEP1A | View in SCUBA |
About the gene
| Chromosome | 18: 32185069-32220404 |
|---|---|
| Predicted location | Membrane, Secreted |
| Essential gene | No |
| Protein class | Enzymes, Predicted membrane proteins, Predicted secreted proteins, Transporters |
| Molecular function | Hydrolase, Metalloprotease, Protease |
| Biological process | Inflammatory response |
Function
Membrane metallopeptidase that sheds many membrane-bound proteins. Exhibits a strong preference for acidic amino acids at the P1' position. Known substrates include: FGF19, VGFA, IL1B, IL18, procollagen I and III, E-cadherin, KLK7, gastrin, ADAM10, tenascin-C. The presence of several pro-inflammatory cytokine among substrates implicate MEP1B in inflammation. It is also involved in tissue remodeling due to its capability to degrade extracellular matrix components. Also cleaves the amyloid precursor protein/APP, thereby releasing neurotoxic amyloid beta peptides
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.