AQP3 — Aquaporin 3 (Gill blood group)
AQP3 belongs to a gene co-expression module in 7 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
AQP3's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Interferon response Anti-viral | ACBD5, BTN2A1, BTN3A2, BTN3A3, CISH, EIF2AK2, ERAP2, GBP1 +23 more | View in SCUBA |
| Endothelial | EC Barrier Integrity Endothelial cell development | ABCB1, ADCY4, ARHGAP31, CRYBG3, EPS8, FGR, FRYL, GULP1 +14 more | View in SCUBA |
| Enterocytes | Villus-tip enterocyte transport Absorption | ABCG2, AQP7, BEND7, C2orf88, CDKN2B, MEP1A, MEP1B | View in SCUBA |
| Gamma-delta T cells | γδT17 Effector Inflammation | CCR6, CEBPD, COLQ, CTSA, CTSH, EDEM2, GCHFR, IL23R +10 more | |
| Innate lymphoid cells | Actin Cytoskeletal Regulation Cytoskeleton & motility | CCDC57, CLPTM1, COTL1, DCAF11, GSN, GYG1, MZT2B, NAA38 +7 more | View in SCUBA |
| Mucosal-associated invariant T cell | Antigen Processing Protein processing & ER | ATP5MJ, CAPNS1, CCDC107, CTDNEP1, NCR3, NSA2, PHB2, PPA1 +8 more | |
| Pericytes | Vascular Tone Homeostasis Housekeeping | ACSL5, AQP1, ASS1, DCHS1, GIT1, NPR1, RUNDC3B, TSPAN13 +1 more | View in SCUBA |
About the gene
| Synonyms | GIL |
|---|---|
| Chromosome | 9: 33441156-33447596 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | Blood group antigen proteins, Metabolic proteins, Plasma proteins, Predicted membrane proteins, Transporters |
| Molecular function | Blood group antigen |
| Biological process | Transport |
Function
Aquaglyceroporins form homotetrameric transmembrane channels, with each monomer independently mediating glycerol and water transport across the plasma membrane along their osmotic gradient. Could also be permeable to urea (By similarity). Also participates in cell permeability to H2O2 and H2O2- mediated signaling. In skin, transports glycerol to the epidermis and stratum corneum, where it maintains hydration, elasticity, and supports lipid biosynthesis for barrier repair (By similarity). In kidney, contributes to the reabsorption of water, helping the body maintain proper fluid balance (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.