Villus-tip enterocyte transport
Gene co-expression module in Enterocytes
| Category | Absorption |
|---|---|
| Genes | 8 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 7 of 8 genes have a known function matching the annotation |
Why this annotation
Brush-border meprins (MEP1A, MEP1B), the xenobiotic efflux transporter ABCG2, and aquaglyceroporins (AQP7, AQP3) mark villus-tip/terminally differentiated enterocytes. These genes mediate solute and water transport and brush-border proteolysis. CDKN2B fits cell-cycle exit at the tip. The module is related to the other absorptive neighbors.
Genes
ABCG2, AQP3, AQP7, BEND7, C2orf88, CDKN2B, MEP1A, MEP1B
Most correlated modules
- Amino acid absorption · correlation 0.95
- Brush-border Nutrient Uptake · correlation 0.94
- Enterocyte lipid metabolism · correlation 0.94
- Colonocyte Solute Transport · correlation 0.93
- Amino acid absorption · correlation 0.93
- Mature enterocyte differentiation · correlation 0.92
- Brush-border nutrient uptake · correlation 0.91
- Chylomicron lipid absorption · correlation 0.91
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.