MERTK — MER proto-oncogene, tyrosine kinase
MERTK belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
MERTK's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Vascular Homeostasis Endothelial cell development | ATP2A3, ATP6V1C2, C19orf33, CP, EMP3, ICAM2, PLLP, PPP1R14A +5 more | View in SCUBA |
| Monocytes | Efferocytosis Tissue Macrophage Lysosomal & pahgocytosis | ADORA3, AKR1B1, CPM, FCHO2, GPR34, PDK4, SLC1A3, STARD13 | View in SCUBA |
About the gene
| Synonyms | c-Eyk, mer, RP38, Tyro12 |
|---|---|
| Chromosome | 2: 111898607-112029561 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | Disease related genes, Enzymes, Human disease related genes, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins |
| Molecular function | Kinase, Receptor, Transferase, Tyrosine-protein kinase |
Function
Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including LGALS3, TUB, TULP1 or GAS6. Regulates many physiological processes including cell survival, migration, differentiation, and phagocytosis of apoptotic cells (efferocytosis). Ligand binding at the cell surface induces autophosphorylation of MERTK on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with GRB2 or PLCG2 and induces phosphorylation of MAPK1, MAPK2, FAK/PTK2 or RAC1. MERTK signaling plays a role in various processes such as macrophage clearance of apoptotic cells, platelet aggregation, cytoskeleton reorganization and engulfment. Functions in the retinal pigment epithelium (RPE) as a regulator of rod outer segments fragments phagocytosis. Also plays an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response by activating STAT1, which selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.