PPP1R14A — Protein phosphatase 1 regulatory inhibitor subunit 14A
PPP1R14A belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
PPP1R14A's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Vascular Homeostasis Endothelial cell development | ATP2A3, ATP6V1C2, C19orf33, CP, EMP3, ICAM2, MERTK, PLLP +5 more | View in SCUBA |
| Fibroblasts | COL13A1+ Deep Fibroblast ECM production | APOC1, BMPER, COL13A1, CSF1, GPR63, GPX3, GRIA3, HAAO +6 more | View in SCUBA |
| Hematopoietic progenitor cells | Megakaryocyte Commitment Myeloid development | ARHGAP6, C2orf88, CLU, ITGA2B, MPIG6B, PRKAR2B, RGS10, RGS18 +1 more | |
| Pericytes | Smooth Muscle Contractile Cytoskeletal | ACTA2, CSRP1, FLNA, MYL9, MYLK, NEXN, S100A4, TAGLN +2 more | View in SCUBA |
| Smooth muscle cells | SMC contractile apparatus Contractility | ACTA2, ACTB, CALD1, CAV1, DSTN, MYL6, MYL9, SH3BGRL +2 more | View in SCUBA |
About the gene
| Synonyms | CPI-17, PPP1INL |
|---|---|
| Chromosome | 19: 38251237-38256532 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Plasma proteins, Predicted intracellular proteins |
| Molecular function | Protein phosphatase inhibitor |
Function
Inhibitor of PPP1CA. Has over 1000-fold higher inhibitory activity when phosphorylated, creating a molecular switch for regulating the phosphorylation status of PPP1CA substrates and smooth muscle contraction
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.