PLLP — Plasmolipin
PLLP belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
PLLP's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Vascular Homeostasis Endothelial cell development | ATP2A3, ATP6V1C2, C19orf33, CP, EMP3, ICAM2, MERTK, PPP1R14A +5 more | View in SCUBA |
| Pericytes | Arterial Pericyte Identity Developmental | ATP13A3, BMX, FBLN2, GJA5, KCTD12, LTC4S, SEMA3G, TMEM100 +1 more | View in SCUBA |
About the gene
| Synonyms | PMLP, TM4SF11 |
|---|---|
| Chromosome | 16: 57248547-57284672 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | Predicted membrane proteins |
Function
Main component of the myelin sheath that plays an important role in myelin membrane biogenesis and myelination. Plays an essential function in apical endocytosis. Regulates epithelial development through the regulation of apical endocytosis (By similarity). Part of the intracellular machinery that mediates basolateral-to-apical transport of ICAM-1, an essential adhesion receptor in epithelial cells, from the subapical compartment in hepatic epithelial cells.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.