Vascular Homeostasis
Gene co-expression module in Endothelial
| Category | Endothelial cell development |
|---|---|
| Genes | 14 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 9 of 14 genes have a known function matching the annotation |
Why this annotation
ICAM2 (endothelial-specific adhesion molecule marking quiescent ECs, downregulated upon activation), SEMA3G (semaphorin expressed in quiescent vasculature for vessel guidance/stability), PRDM16 (transcription factor in vascular development), RRAS (R-Ras, promotes EC quiescence and integrin-mediated adhesion), MERTK (TAM receptor involved in efferocytosis and vascular homeostasis), PPP1R14A (smooth muscle/EC contractility regulator). Strongly downregulated in both UC and CD inflammation with robust recovery in remission — the strongest inflammation-suppressed module in this batch. This represents a quiescent vascular homeostasis program.
Genes
ATP2A3, ATP6V1C2, C19orf33, CP, EMP3, ICAM2, MERTK, PLLP, PPP1R14A, PRDM16, RRAS, SEMA3G, SORT1, USP54
Most correlated modules
- Arterial EC Identity · correlation 0.89
- EC Inflammatory Activation · correlation 0.89
- Arterial EC Identity · correlation 0.88
- Cytoskeletal Scaffolding · correlation 0.88
- EC Quiescence Identity · correlation 0.86
- Endothelial Quiescence · correlation 0.82
- Inflammatory Angiogenesis · correlation 0.81
- EC Barrier Integrity · correlation 0.80
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.