METTL21A — Methyltransferase 21A, HSPA lysine
METTL21A belongs to a gene co-expression module in 1 of 30 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
METTL21A's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Colonocytes | BEST4 Colonocyte Identity Epithelial development | ADRA2A, AOAH, CCNJL, CDC14A, CENPJ, CNTFR, EEF2K, EXD3 +25 more | View in SCUBA |
About the gene
| Synonyms | FAM119A, HCA557b, HSPA-KMT, LOC151194 |
|---|---|
| Chromosome | 2: 207580631-207625928 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | Predicted intracellular proteins, Predicted membrane proteins |
| Molecular function | Methyltransferase, Transferase |
Function
Protein-lysine methyltransferase that selectively trimethylates residues in heat shock protein 70 (HSP70) family members. Contributes to the in vivo trimethylation of Lys residues in HSPA1 and HSPA8. In vitro methylates 'Lys-561' in HSPA1, 'Lys-564' in HSPA2, 'Lys-585' in HSPA5, 'Lys-563' in HSPA6 and 'Lys-561' in HSPA8.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.