BEST4 Colonocyte Identity
Gene co-expression module in Colonocytes
| Category | Epithelial development |
|---|---|
| Genes | 0 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 15 of 34 genes have a known function matching the annotation |
Why this annotation
OTOP2 (138.7x BEST4) and OTOP3 (126.7x BEST4) are proton channels that are defining markers of BEST4+ colonocytes. GUCA2A (uroguanylin, 12.6x sen_colono) and GUCA2B (guanylin, 8.8x sen_colono) are guanylin peptides that activate guanylate cyclase C. PRKG2 (cGMP-dependent kinase 2) mediates downstream guanylin/cGMP signaling for fluid secretion. PCSK1N (31.3x BEST4), MYOM1 (30.7x BEST4), SLC2A5/GLUT5 (13.7x BEST4), SCRN1 (7.1x BEST4), CCNJL (6.1x BEST4), FRMD1 (3.6x BEST4), VIPR1 (VIP receptor), ADRA2A (adrenergic receptor), and LYPD8 (colonocyte luminal surface) further define BEST4 colonocyte identity. This module clearly represents the BEST4 colonocyte transcriptional program with guanylin/cGMP signaling.
Genes
Most correlated modules
- Cytoskeletal Remodeling · correlation 0.85
- BEST4+ Colonocyte Identity · correlation 0.53
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.