CDC14A — Cell division cycle 14A
CDC14A belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CDC14A's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Resting memory T cell Immune regulation | ANXA1, CD300A, CYB561, DHRS3, DYNLT3, IL7R, MYADM, NECTIN3 +5 more | View in SCUBA |
| Enterocytes | Mature enterocyte differentiation Absorption | ABCC2, ACSF2, AOC1, CEP350, EEPD1, EPS8L2, GRAMD1C, MXI1 +5 more | View in SCUBA |
| Gamma-delta T cells | TCR Signal Regulation TCR Signaling | ADORA2A, ANO9, CAMK4, CASK, CCR5, CD84, CXCR6, DGKA +22 more | |
| Mucosal-associated invariant T cell | Calcineurin-NFAT Signaling TCR Signaling | AKT3, IQGAP2, NCALD, NEK7, PLCB1, PLCL2, PPP2R2B, PPP3CA +3 more |
About the gene
| Synonyms | cdc14, Cdc14A1, Cdc14A2, DFNB105, DFNB32 |
|---|---|
| Chromosome | 1: 100345001-100520277 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Enzymes, Human disease related genes, Plasma proteins, Potential drug targets, Predicted intracellular proteins |
| Molecular function | Hydrolase, Protein phosphatase |
| Biological process | Cell cycle, Cell division, Hearing |
Function
Dual-specificity phosphatase. Required for centrosome separation and productive cytokinesis during cell division. Dephosphorylates SIRT2 around early anaphase. May dephosphorylate the APC subunit FZR1/CDH1, thereby promoting APC-FZR1 dependent degradation of mitotic cyclins and subsequent exit from mitosis. Required for normal hearing.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.