MSL3 — MSL complex subunit 3
MSL3 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
MSL3's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | T-cell quiescence regulation Immune regulation | CDC42SE2, CDKN1B, FOXP1, ICAM2, KRAS, MRPS6, SERINC5, SLC5A3 +4 more | View in SCUBA |
| Endothelial | Actin Vesicle Trafficking Cytoskeletal | ABRACL, ACTR3, ADRM1, ANKRD9, C3orf14, CISD2, CLIC1, EIF2S1 +10 more | View in SCUBA |
| Neutrophils | Neutrophil Differentiation Developmental | ABTB1, FRAT2, GCA, ICAM3, MANSC1, MNDA, NFE2, QPCT +2 more |
About the gene
| Synonyms | MSL3L1 |
|---|---|
| Chromosome | X: 11758159-11775772 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins |
| Molecular function | Chromatin regulator, DNA-binding |
| Biological process | Transcription, Transcription regulation |
Function
Non-catalytic component of the MSL histone acetyltransferase complex, a multiprotein complex that mediates the majority of histone H4 acetylation at 'Lys-16' (H4K16ac), an epigenetic mark that prevents chromatin compaction. The MSL complex is required for chromosome stability and genome integrity by maintaining homeostatic levels of H4K16ac. The MSL complex is also involved in gene dosage by promoting up-regulation of genes expressed by the X chromosome (By similarity). X up-regulation is required to compensate for autosomal biallelic expression (By similarity). The MSL complex also participates in gene dosage compensation by promoting expression of Tsix non-coding RNA (By similarity). Acts as a histone reader that specifically recognizes and binds histone H4 monomethylated at 'Lys-20' (H4K20Me1) in a DNA-dependent manner and is proposed to be involved in chromosomal targeting of the MSL complex. May play a role X inactivation in females.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.