CLIC1 — Chloride intracellular channel 1
CLIC1 belongs to a gene co-expression module in 13 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CLIC1's module in each cell type
About the gene
| Synonyms | CLCNL1, G6, NCC27, p64CLCP |
|---|---|
| Chromosome | 6: 31730581-31739763 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Cancer-related genes, Plasma proteins, Predicted intracellular proteins, Transporters |
| Molecular function | Chloride channel, Ion channel, Oxidoreductase, Voltage-gated channel |
| Biological process | Ion transport, Transport |
Function
In the soluble state, catalyzes glutaredoxin-like thiol disulfide exchange reactions with reduced glutathione as electron donor. Reduces selenite and dehydroascorbate and may act as an antioxidant during oxidative stress response. Can insert into membranes and form voltage-dependent multi-ion conductive channels. Membrane insertion seems to be redox- regulated and may occur only under oxidizing conditions. Involved in regulation of the cell cycle.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.