Actin Vesicle Trafficking
Gene co-expression module in Endothelial
| Category | Cytoskeletal |
|---|---|
| Genes | 19 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 9 of 19 genes have a known function matching the annotation |
Why this annotation
Hub genes ACTR3 (Arp2/3 complex subunit, actin nucleation/branching), ABRACL (actin-related, Arp2/3 activator), and MYO5A (myosin Va, actin-based vesicle transport) define an actin dynamics and vesicle trafficking program. VAPA (VAMP-associated protein A) mediates ER-vesicle contacts and lipid transfer. ADRM1 (proteasome ubiquitin receptor) links to protein turnover. Lipid metabolism genes ELOVL1 (fatty acid elongase), SPTSSA (sphingolipid synthesis), SQLE (cholesterol synthesis), and PAPSS1 (sulfation) suggest membrane lipid remodeling accompanying cytoskeletal changes. CLIC1 is a chloride channel involved in cell volume regulation during migration. The module is significantly upregulated in UC and CD inflammation. The actin branching/vesicle trafficking theme (ACTR3, ABRACL, MYO5A, VAPA) is most prominent, consistent with endothelial vesicle exocytosis and transcytosis during inflammation. Neighbor context: complements M19 kinase signaling with downstream cytoskeletal effectors.
Genes
ABRACL, ACTR3, ADRM1, ANKRD9, C3orf14, CISD2, CLIC1, EIF2S1, ELOVL1, KLHL42, LSM1, MSL3, MYO5A, PAPSS1, PGM2, SPTSSA, SQLE, VAPA, ZDHHC13
Most correlated modules
- ER Calcium Stress · correlation 0.94
- Proteasomal Degradation · correlation 0.93
- mRNA Splicing Stress · correlation 0.92
- Actin Cytoskeletal Remodeling · correlation 0.91
- ER Protein Processing · correlation 0.89
- Glycolysis Activation · correlation 0.88
- ER-Golgi Trafficking · correlation 0.87
- Inflammatory Lipid Metabolism · correlation 0.87
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.