CISD2 — CDGSH iron sulfur domain 2
CISD2 belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CISD2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Activated effector Tcell Immune regulation | APOBEC3C, ARPP19, CTSC, ENTPD1, GLUD1, IL2RB, LYST, MICAL2 +4 more | View in SCUBA |
| CD8⁺ T cells | Cellular Housekeeping Housekeeping | ACAT2, ACOT7, FDPS, NUDT21, PA2G4, PPIA, PSMC3, PSMG2 +9 more | View in SCUBA |
| Endothelial | Actin Vesicle Trafficking Cytoskeletal | ABRACL, ACTR3, ADRM1, ANKRD9, C3orf14, CLIC1, EIF2S1, ELOVL1 +10 more | View in SCUBA |
| Innate lymphoid cells | Mixed Proteostasis Metabolism Metabolism | ADRM1, ANXA11, ATP6V0B, COX17, DNAJC8, DR1, EIF3I, HPRT1 +18 more | View in SCUBA |
| Macrophages | Mixed Housekeeping Housekeeping | AP2M1, BAG1, CHMP4A, COA6, CSNK2B, CYB5R3, DEGS1, DYNLRB1 +20 more | View in SCUBA |
About the gene
| Synonyms | ERIS, Miner1, NAF-1, WFS2, ZCD2 |
|---|---|
| Chromosome | 4: 102868974-102892807 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | Disease related genes, Human disease related genes, Predicted membrane proteins |
| Biological process | Autophagy |
Function
Regulator of autophagy that contributes to antagonize BECN1- mediated cellular autophagy at the endoplasmic reticulum. Participates in the interaction of BCL2 with BECN1 and is required for BCL2-mediated depression of endoplasmic reticulum Ca(2+) stores during autophagy. Contributes to BIK-initiated autophagy, while it is not involved in BIK-dependent activation of caspases. Involved in life span control, probably via its function as regulator of autophagy
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.