NPL — N-acetylneuraminate pyruvate lyase
NPL belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
NPL's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Monocytes | IL-18 Inflammasome Response Inflammatory | CTTNBP2, DEPTOR, EPS8, IL18, LHFPL6, ME1, RNF141, SHMT1 | View in SCUBA |
About the gene
| Synonyms | C1orf13, DHDPS1, NPL1 |
|---|---|
| Chromosome | 1: 182789293-182830384 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Enzymes, Metabolic proteins, Predicted intracellular proteins |
| Molecular function | Lyase |
| Biological process | Carbohydrate metabolism |
Function
Catalyzes the cleavage of N-acetylneuraminic acid (sialic acid) to form pyruvate and N-acetylmannosamine via a Schiff base intermediate. It prevents sialic acids from being recycled and returning to the cell surface. Involved in the N-glycolylneuraminic acid (Neu5Gc) degradation pathway. Although human is not able to catalyze formation of Neu5Gc due to the inactive CMAHP enzyme, Neu5Gc is present in food and must be degraded (Probable).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.