ME1 — Malic enzyme 1
ME1 belongs to a gene co-expression module in 6 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
ME1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Cytokine signaling Immune regulation | ABCB1, ARHGEF40, AUTS2, COLQ, DSE, ERN1, GPR65, IFI44 +12 more | View in SCUBA |
| Enterocytes | ER chaperone/UPR Protein processing & ER | ANXA2, CALR, EFNB2, ENO1, HSP90B1, HSPA5, MARCKS, PDIA3 +3 more | View in SCUBA |
| Gamma-delta T cells | γδT17 Effector Inflammation | AQP3, CCR6, CEBPD, COLQ, CTSA, CTSH, EDEM2, GCHFR +10 more | |
| Macrophages | Myeloid Signaling Regulation Innate immunity | ADGRG6, AOAH, CCDC170, CD302, CMKLR1, CPED1, DIPK2A, FAM13A +38 more | View in SCUBA |
| Monocytes | IL-18 Inflammasome Response Inflammatory | CTTNBP2, DEPTOR, EPS8, IL18, LHFPL6, NPL, RNF141, SHMT1 | View in SCUBA |
| Mucosal-associated invariant T cell | IL-18 Innate Activation Inflammation | ADAM10, COLQ, IL18RAP, KIF5C, MYBL1, NEO1, P2RY14, PARP8 +3 more |
About the gene
| Chromosome | 6: 83210402-83431051 |
|---|---|
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins |
| Molecular function | Oxidoreductase |
Function
Catalyzes the oxidative decarboxylation of (S)-malate in the presence of NADP(+) and divalent metal ions, and decarboxylation of oxaloacetate.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.