DEPTOR — DEP domain containing MTOR interacting protein
DEPTOR belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
DEPTOR's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Enterocytes | Spectrin-actin scaffold Cytoskeletal | ADD3, DNAAF9, FYB2, MBOAT2, PRKCB, SETBP1, SIPA1L2, SNTB1 +2 more | View in SCUBA |
| Hematopoietic progenitor cells | HSC Stemness Program Stemness | ADRA2A, ALDH1A1, ATP6V0A2, CPPED1, FCER1A, FREM1, PBX1, PGAP4 +4 more | |
| Monocytes | IL-18 Inflammasome Response Inflammatory | CTTNBP2, EPS8, IL18, LHFPL6, ME1, NPL, RNF141, SHMT1 | View in SCUBA |
About the gene
| Synonyms | DEP.6, DEPDC6, FLJ12428 |
|---|---|
| Chromosome | 8: 119873717-120050918 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
Function
Negative regulator of the mTORC1 and mTORC2 complexes: inhibits the protein kinase activity of MTOR, thereby inactivating both complexes. DEPTOR inhibits mTORC1 and mTORC2 to induce autophagy. In contrast to AKT1S1/PRAS40, only partially inhibits mTORC1 activity.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.