NPR1 — Natriuretic peptide receptor 1
NPR1 belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
NPR1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Pericytes | Vascular Tone Homeostasis Housekeeping | ACSL5, AQP1, AQP3, ASS1, DCHS1, GIT1, RUNDC3B, TSPAN13 +1 more | View in SCUBA |
About the gene
| Synonyms | ANPa, ANPRA, GUCY2A, NPRA |
|---|---|
| Chromosome | 1: 153678688-153693992 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | Enzymes, FDA approved drug targets, Metabolic proteins, Predicted membrane proteins, Transporters |
| Molecular function | Lyase, Receptor, Vasoactive |
| Biological process | cGMP biosynthesis |
Function
Receptor for the atrial natriuretic peptide NPPA/ANP and the brain natriuretic peptide NPPB/BNP which are potent vasoactive hormones playing a key role in cardiovascular homeostasis. Plays an essential role in the regulation of endothelial cell senescence and vascular aging. Upon activation by ANP or BNP, stimulates the production of cyclic guanosine monophosphate (cGMP) that promotes vascular tone and volume homeostasis by activation of protein kinase cGMP-dependent 1/PRKG1 and subsequently PRKAA1, thereby controlling blood pressure and maintaining cardiovascular homeostasis.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.