Vascular Tone Homeostasis
Gene co-expression module in Pericytes
| Category | Housekeeping |
|---|---|
| Genes | 10 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 8 of 10 genes have a known function matching the annotation |
Why this annotation
Hub genes include AQP1 and AQP3 (aquaporins mediating water transport, canonical pericyte/endothelial markers), NPR1 (natriuretic peptide receptor regulating vascular tone and fluid balance), ASS1 (argininosuccinate synthase feeding into NO synthesis and vascular tone), TSPAN13/TSPAN18 (tetraspanins in membrane organization), and GIT1 (focal adhesion/vascular signaling). Together these genes define a vascular fluid homeostasis and tone-regulation program. Downregulated in CD inflammation and restored in UC remission, consistent with loss of pericyte homeostatic function during intestinal inflammation. Neighbor M25 shares tetraspanin (TSPAN7) and vascular identity genes, supporting a vascular homeostasis neighborhood.
Genes
ACSL5, AQP1, AQP3, ASS1, DCHS1, GIT1, NPR1, RUNDC3B, TSPAN13, TSPAN18
Most correlated modules
- Notch Vascular Development · correlation 0.97
- Rho GTPase Signaling · correlation 0.96
- MHC-II Antigen Presentation · correlation 0.95
- Angiogenic Receptor Signaling · correlation 0.94
- Vascular Barrier Integrity · correlation 0.94
- Vascular Junction Adhesion · correlation 0.94
- Arterial Identity TFs · correlation 0.94
- Arterial Notch Signaling · correlation 0.94
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.