ASS1 — Argininosuccinate synthase 1
ASS1 belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
ASS1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Arterial EC Identity Endothelial cell development | ABR, AIF1L, CCDC88C, CPNE8, EPHA4, IFITM2, MOB2, RAB30 +5 more | View in SCUBA |
| Enterocytes | Mature colonocyte metabolism Nutrient metabolism | ANXA4, ATP1B3, BTNL3, CORO2A, HMCN2, MGAT4A, MOB3B, MTUS1 +6 more | View in SCUBA |
| Goblet cells | Mucin Glycosylation Remodeling Mucus production & secretion | B3GNT6, DNAJC12, FFAR4, GALE, PARM1, SERPINA1, ST3GAL4 | View in SCUBA |
| Pericytes | Vascular Tone Homeostasis Housekeeping | ACSL5, AQP1, AQP3, DCHS1, GIT1, NPR1, RUNDC3B, TSPAN13 +1 more | View in SCUBA |
About the gene
| Synonyms | ASS, CTLN1 |
|---|---|
| Chromosome | 9: 130444961-130501274 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins |
| Molecular function | Ligase |
| Biological process | Amino-acid biosynthesis, Arginine biosynthesis, Urea cycle |
Function
One of the enzymes of the urea cycle, the metabolic pathway transforming neurotoxic amonia produced by protein catabolism into inocuous urea in the liver of ureotelic animals. Catalyzes the formation of arginosuccinate from aspartate, citrulline and ATP and together with ASL it is responsible for the biosynthesis of arginine in most body tissues.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.