NR2F6 — Nuclear receptor subfamily 2 group F member 6
NR2F6 belongs to a gene co-expression module in 1 of 30 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
NR2F6's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Colonocytes | Integrin Adhesion Signaling migration & adhesion | ARF1, C1GALT1, C1orf210, CCNI, CD164, CFL1, CMPK1, DIAPH1 +26 more | View in SCUBA |
About the gene
| Synonyms | EAR-2, EAR2, ERBAL2 |
|---|---|
| Chromosome | 19: 17231883-17245919 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Nuclear receptors, Predicted intracellular proteins, Transcription factors |
| Molecular function | DNA-binding, Receptor, Repressor |
| Biological process | Transcription, Transcription regulation |
Function
Transcription factor predominantly involved in transcriptional repression. Binds to promoter/enhancer response elements that contain the imperfect 5'-AGGTCA-3' direct or inverted repeats with various spacings which are also recognized by other nuclear hormone receptors. Involved in modulation of hormonal responses. Represses transcriptional activity of the lutropin- choriogonadotropic hormone receptor/LHCGR gene, the renin/REN gene and the oxytocin-neurophysin/OXT gene. Represses the triiodothyronine- dependent and -independent transcriptional activity of the thyroid hormone receptor gene in a cell type-specific manner. The corepressing function towards thyroid hormone receptor beta/THRB involves at least in part the inhibition of THRB binding to triiodothyronine response elements (TREs) by NR2F6. Inhibits NFATC transcription factor DNA binding and subsequently its transcriptional activity. Acts as transcriptional repressor of IL-17 expression in Th-17 differentiated CD4(+) T cells and may be involved in induction and/or maintenance of peripheral immunological tolerance and autoimmunity. Involved in development of forebrain circadian clock; is required early in the development of the locus coeruleus (LC).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.