C1GALT1 — Core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1
C1GALT1 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
C1GALT1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | TCR Complex Activation TCR/AP1/NFKb pathway | ABHD17A, ACTR3, CD2, CD3D, CD3E, CD3G, CD81, CERK +14 more | View in SCUBA |
| Macrophages | General Cellular Maintenance Housekeeping | ABHD13, AKT2, AMD1, DCUN1D1, FBXL3, FMR1, GAK, GCC2 +13 more | View in SCUBA |
About the gene
| Synonyms | C1GALT, T-synthase |
|---|---|
| Chromosome | 7: 7156934-7248616 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Enzymes, Metabolic proteins, Predicted intracellular proteins |
| Molecular function | Developmental protein, Glycosyltransferase, Transferase |
| Biological process | Angiogenesis, Differentiation |
Function
Glycosyltransferase that generates the core 1 O-glycan Gal- beta1-3GalNAc-alpha1-Ser/Thr (T antigen), which is a precursor for many extended O-glycans in glycoproteins. Plays a central role in many processes, such as angiogenesis, thrombopoiesis and kidney homeostasis development (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.