CMPK1 — Cytidine/uridine monophosphate kinase 1
CMPK1 belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CMPK1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | mRNA Splicing Processing RNA processing | ANXA2R, APOL3, BTN3A1, CCNL1, CHCHD7, DDX5, EIF4A2, EIF5 +7 more | View in SCUBA |
| Endothelial | Chromatin Cell Cycle DNA/chromatin regulation | ARPP19, BRD7, CCPG1, IPO9, MBD2, PDS5B, TM9SF2 | View in SCUBA |
| Enterocytes | Colonocyte terminal differentiation Epithelial development | CCDC186, CEACAM1, FHL2, GCNT3, HKDC1, IFNGR1, LRRFIP1, PTP4A1 +2 more | View in SCUBA |
| Innate lymphoid cells | Translation Initiation RNA processing & translation | ATP5PO, CCNI, CDC42, COX4I1, COX7A2L, EIF3D, EIF3E, EIF3H +6 more | View in SCUBA |
| Macrophages | ER Morphology Stress Stress | ARMC1, ARPP19, ATL3, CYB5B, EIF2AK1, ELAVL1, ERGIC2, HDAC2 +8 more | View in SCUBA |
About the gene
| Synonyms | CMPK, UMP-CMPK |
|---|---|
| Chromosome | 1: 47333790-47394866 |
| Predicted location | Intracellular |
| Essential gene | Yes |
| Protein class | Enzymes, Essential proteins, Metabolic proteins, Plasma proteins, Predicted intracellular proteins |
| Molecular function | Kinase, Transferase |
| Biological process | Pyrimidine biosynthesis |
Function
Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors. Also displays broad nucleoside diphosphate kinase activity.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.