Integrin Adhesion Signaling
Gene co-expression module in Colonocytes
| Category | migration & adhesion |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 10 of 35 genes have a known function matching the annotation |
Why this annotation
Hub genes include ITGB1 (integrin β1), PAK2 (p21-activated kinase downstream of RAC1/CDC42), DIAPH1 (formin, linear actin polymerization), CFL1 (cofilin, actin severing), and EPCAM. TAX1BP1 links to NF-κB/autophagy. SDC1 (syndecan-1) and ITGB1 are canonical integrin adhesion components. ARF1 and RAB5A contribute vesicle trafficking. LGR4 is a Wnt/R-spondin receptor. The module is strongly upregulated in UC inflammation. Compared to M10 (Arp2/3 branching), this module captures integrin-mediated adhesion signaling coupled to formin/cofilin actin remodeling — a distinct but complementary cytoskeletal program. DIAPH1 is a formin downstream of RHO, contrasting with RAC1-Arp2/3 in M10.
Genes
Most correlated modules
- Arp2/3 Actin Branching · correlation 0.96
- Epithelial Junction Integrity · correlation 0.93
- Ubiquitin Signaling Response · correlation 0.90
- mTOR Lysosomal Sensing · correlation 0.90
- Endosomal Vesicle Trafficking · correlation 0.90
- Hypoxic Oxidative Stress · correlation 0.90
- Lysosomal Autophagy Trafficking · correlation 0.89
- Membrane Repair Response · correlation 0.88
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.