CFL1 — Cofilin 1
CFL1 belongs to a gene co-expression module in 14 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CFL1's module in each cell type
About the gene
| Synonyms | CFL |
|---|---|
| Chromosome | 11: 65823022-65862026 |
| Predicted location | Intracellular |
| Essential gene | Yes |
| Protein class | Essential proteins, Plasma proteins, Predicted intracellular proteins |
| Molecular function | Actin-binding |
| Biological process | Host-virus interaction |
Function
Binds to F-actin and exhibits pH-sensitive F-actin depolymerizing activity. In conjunction with the subcortical maternal complex (SCMC), plays an essential role for zygotes to progress beyond the first embryonic cell divisions via regulation of actin dynamics. Required for the centralization of the mitotic spindle and symmetric division of zygotes (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization in epithelial cells. Required for the up-regulation of atypical chemokine receptor ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation. Required for neural tube morphogenesis and neural crest cell migration (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.