DIAPH1 — Diaphanous related formin 1
DIAPH1 belongs to a gene co-expression module in 6 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
DIAPH1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | ER/vesicle trafficking Protein processing & ER | ATP6V0B, CD99, HCST, M6PR, MTDH, MTPN, REEP5, SCPEP1 +1 more | View in SCUBA |
| CD4⁺ T cells | Integrin Adhesion Migration migration & adhesion | ARAP2, ATF7IP, C4orf3, CLEC2B, COTL1, CTSH, DEK, EML4 +11 more | View in SCUBA |
| Endothelial | mRNA Splicing RNA processing & translation | EIF4A3, FUBP1, GLRX5, HNRNPA2B1, HNRNPA3, HNRNPD, KHDRBS1, MAGOH +8 more | View in SCUBA |
| Gamma-delta T cells | TCR Activation Signaling TCR Signaling | ADCY7, ATP2B4, CYFIP2, GK5, GLG1, ITGAL, NBEAL2, NFATC3 +4 more | |
| Mucosal-associated invariant T cell | Cytoskeletal Migration migration & adhesion | AGTPBP1, AHNAK, ATP2B4, FLNA, IQSEC1, ITCH, ITGA4, OGDH +8 more | |
| Pericytes | Actin-ERM Migration Cytoskeletal | CRIP2, FKBP1A, FXYD5, ITGA5, MRPL17, MSN, NAA38, RDX | View in SCUBA |
About the gene
| Synonyms | DFNA1, hDIA1, LFHL1, mDia1 |
|---|---|
| Chromosome | 5: 141515016-141619055 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Cancer-related genes, Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins |
| Molecular function | Actin-binding |
| Biological process | Hearing |
Function
Actin nucleation and elongation factor required for the assembly of F-actin structures, such as actin cables and stress fibers (By similarity). Binds to the barbed end of the actin filament and slows down actin polymerization and depolymerization (By similarity). Required for cytokinesis, and transcriptional activation of the serum response factor (By similarity). DFR proteins couple Rho and Src tyrosine kinase during signaling and the regulation of actin dynamics (By similarity). Functions as a scaffold protein for MAPRE1 and APC to stabilize microtubules and promote cell migration (By similarity). Has neurite outgrowth promoting activity. Acts in a Rho-dependent manner to recruit PFY1 to the membrane (By similarity). In hear cells, it may play a role in the regulation of actin polymerization in hair cells. The MEMO1-RHOA- DIAPH1 signaling pathway plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. It controls the localization of APC and CLASP2 to the cell membrane, via the regulation of GSK3B activity. In turn, membrane-bound APC allows the localization of the MACF1 to the cell membrane, which is required for microtubule capture and stabilization. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape. Plays a role in brain development. Also acts as an actin nucleation and elongation factor in the nucleus by promoting nuclear actin polymerization inside the nucleus to drive serum-dependent SRF-MRTFA activity (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.