NT5M — 5',3'-nucleotidase, mitochondrial
NT5M belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
NT5M's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Hematopoietic progenitor cells | Erythro-Megakaryocytic Development Erythropoietic | CAMLG, HACD1, ICAM4, IL1B, LYL1, MPP1, NFE2, PLEK +1 more |
About the gene
| Synonyms | dNT-2, dNT2, mdN |
|---|---|
| Chromosome | 17: 17303335-17347663 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Metabolic proteins, Predicted intracellular proteins |
| Molecular function | Hydrolase |
| Biological process | Nucleotide metabolism |
Function
Dephosphorylates specifically the 5' and 2'(3')-phosphates of uracil and thymine deoxyribonucleotides, and so protects mitochondrial DNA replication from excess dTTP. Has only marginal activity towards dIMP and dGMP
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.