SCUBA

PLEK — Pleckstrin

PLEK belongs to a gene co-expression module in 9 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

PLEK's module in each cell type

Cell typeModuleShares the module with
CD19⁺ B cellsB cell activation
BCR/AP1/NFKb pathway
ADGRG5, BCAR3, CD86, CLIP2, CNOT2, CTSH, FAS, GABARAPL2 +7 moreView in SCUBA
CD4⁺ T cellsLAYN+ tissue Treg
Immune regulation
BEX3, CADM1, CHRNA6, EPHX2, FLVCR2, GNG8, IKZF4, LAPTM4B +7 moreView in SCUBA
CD8⁺ T cellsEffector Memory CD8
T cell maturation
CLDND1, DENND2D, GIMAP1, GIMAP4, GIMAP7, GPR183, GZMK, ITM2C +3 moreView in SCUBA
Gamma-delta T cellsTCR Proximal Signaling
TCR Signaling
ADGRG5, BIN2, C11orf21, C12orf75, CD300A, FGR, GPSM3, LAT +11 more
Hematopoietic progenitor cellsErythro-Megakaryocytic Development
Erythropoietic
CAMLG, HACD1, ICAM4, IL1B, LYL1, MPP1, NFE2, NT5M +1 more
MonocytesEpigenetic Inflammatory Reprogramming
Inflammatory
BHLHE40, EHD1, KDM6B, PHACTR1, PPIF, SMAD7, SOD2, ZNF267View in SCUBA
Mucosal-associated invariant T cellMature Effector MAIT
T cell maturation
ADD3, ANTKMT, APOBEC3G, CCL5, CXXC5, FHL3, GZMK, ITGA6 +7 more
Natural Killer cellsInnate Sensing NK Regulation
Immune regulation
ADRB2, DTHD1, FCRL6, LFNG, LIMD2, PRR5L, PYHIN1, UBE2F +1 moreView in SCUBA
NeutrophilsNF-κB Activation
Inflammatory
EHD1, GRAMD1A, NBN, NFKB2, NFKBIA, NFKBIZ, PLAUR, PLK3 +6 more

About the gene

SynonymsP47, PLEK1
Chromosome2: 68365282-68397453
Predicted locationIntracellular
Essential geneNo
Protein classPlasma proteins, Predicted intracellular proteins

Function

Major protein kinase C substrate of platelets

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.