IL1B — Interleukin 1 beta
IL1B belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
IL1B's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Hematopoietic progenitor cells | Erythro-Megakaryocytic Development Erythropoietic | CAMLG, HACD1, ICAM4, LYL1, MPP1, NFE2, NT5M, PLEK +1 more | |
| Macrophages | NF-κB Inflammatory Activation Inflammatory | ADM, CCL2, CCL20, CCL7, CLEC4E, CXCL1, CXCL2, CXCL3 +19 more | View in SCUBA |
| Monocytes | Inflammatory Stress Response Stress | ARL5B, ATF3, CCRL2, CD83, DUSP10, NFE2L2, RASGEF1B, SGK1 +2 more | View in SCUBA |
| Neutrophils | Inflammasome IL-1 Response Cytokine & chemokine secretion | CSRNP1, EGR3, G0S2, IER3, IFRD1, IL1RN, IVNS1ABP, LPCAT1 +5 more |
About the gene
| Synonyms | IL-1B, IL1-BETA, IL1F2 |
|---|---|
| Chromosome | 2: 112829751-112836816 |
| Predicted location | Intracellular, Secreted |
| Essential gene | No |
| Protein class | Cancer-related genes, Candidate cardiovascular disease genes, FDA approved drug targets, Human disease related genes, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins, Transporters |
| Molecular function | Cytokine, Mitogen, Pyrogen |
| Biological process | Inflammatory response |
Function
Potent pro-inflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B-cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T-helper 1 (Th1) cells. Plays a role in angiogenesis by inducing VEGF production synergistically with TNF and IL6. Involved in transduction of inflammation downstream of pyroptosis: its mature form is specifically released in the extracellular milieu by passing through the gasdermin-D (GSDMD) pore. Acts as a sensor of S.pyogenes infection in skin: cleaved and activated by pyogenes SpeB protease, leading to an inflammatory response that prevents bacterial growth during invasive skin infection.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.