ICAM4 — Intercellular adhesion molecule 4 (Landsteiner-Wiener blood group)
ICAM4 belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
ICAM4's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | NF-kB activation TCR/AP1/NFKb pathway | ADRA2B, CD83, CHD4, CYB5D1, DUSP2, EGR2, EGR3, EGR4 +9 more | View in SCUBA |
| Endothelial | Integrated Stress Response Stress | ARL5B, ATF3, CCNL1, CD83, CDKN1A, DDIT3, IRF1, KDM6B +3 more | View in SCUBA |
| Fibroblasts | Type I Interferon Inflammatory | ABHD5, HELZ2, IQCN, IRF7, IRF8, IRF9, LACTB, MYLIP +2 more | View in SCUBA |
| Hematopoietic progenitor cells | Erythro-Megakaryocytic Development Erythropoietic | CAMLG, HACD1, IL1B, LYL1, MPP1, NFE2, NT5M, PLEK +1 more | |
| Macrophages | NF-κB Effector Response Inflammatory | ARL5B, BIRC3, CYB5D1, DUSP2, EGR3, HES1, PTGS2, SIK1 | View in SCUBA |
About the gene
| Synonyms | CD242, LW |
|---|---|
| Chromosome | 19: 10286955-10288522 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | Blood group antigen proteins, CD markers, Predicted intracellular proteins, Predicted membrane proteins |
| Molecular function | Blood group antigen |
| Biological process | Cell adhesion |
Function
ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). ICAM4 is also a ligand for alpha- 4/beta-1 and alpha-V integrins
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.