Erythro-Megakaryocytic Development
Gene co-expression module in Hematopoietic progenitor cells
| Category | Erythropoietic |
|---|---|
| Genes | 10 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 7 of 10 genes have a known function matching the annotation |
Why this annotation
NFE2 is a master transcription factor for erythroid and megakaryocyte differentiation. LYL1 is a bHLH TF critical for hematopoietic progenitor and erythroid development. MPP1 (membrane palmitoylated protein 1) is a scaffolding protein highly expressed in erythroid cells. ICAM4 (LW blood group antigen) is an erythroid-specific adhesion molecule. PLEK (pleckstrin) is expressed in megakaryocytes/platelets and myeloid cells. HACD1 is involved in lipid elongation during erythroid maturation. Together these define an erythro-megakaryocytic developmental program. Neighbor context: sits adjacent to M23 (canonical erythropoiesis), reinforcing erythroid identity.
Genes
CAMLG, HACD1, ICAM4, IL1B, LYL1, MPP1, NFE2, NT5M, PLEK, RTN3
Most correlated modules
- Oxidative Stress Survival · correlation 0.90
- Erythroid Progenitor Program · correlation 0.88
- General Metabolic Housekeeping · correlation 0.87
- HSC Progenitor Proliferation · correlation 0.87
- HSC Stemness Program · correlation 0.85
- Replication Stress Response · correlation 0.82
- Erythroid Differentiation · correlation 0.82
- Biosynthetic Housekeeping · correlation 0.81
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.