NUBP1 — NUBP iron-sulfur cluster assembly factor 1, cytosolic
NUBP1 belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
NUBP1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Macrophages | Inflammasome Oxidative Stress Inflammatory | ABI3, ADISSP, AKR1A1, ARHGDIB, ARPC1B, ASCL2, BLVRA, C1orf54 +33 more | View in SCUBA |
About the gene
| Synonyms | CIAO5, NBP1, NBP35 |
|---|---|
| Chromosome | 16: 10743786-10769351 |
| Predicted location | Intracellular |
| Essential gene | Yes |
| Protein class | Essential proteins, Predicted intracellular proteins |
| Biological process | Cilium biogenesis/degradation |
Function
Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NUBP1-NUBP2 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins. Implicated in the regulation of centrosome duplication (By similarity). Negatively regulates cilium formation and structure (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.