Inflammasome Oxidative Stress
Gene co-expression module in Macrophages
| Category | Inflammatory |
|---|---|
| Genes | 42 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 7 of 42 genes have a known function matching the annotation |
Why this annotation
PYCARD (ASC/TMS1) is the inflammasome adaptor protein essential for NLRP3/AIM2 inflammasome assembly and caspase-1 activation. PRDX2 is a peroxiredoxin that scavenges reactive oxygen species and modulates inflammasome activation. GSTK1 and MGST2 are glutathione S-transferases involved in oxidative stress defense. AKR1A1 is an aldo-keto reductase involved in detoxification. VAMP8 mediates vesicle fusion in secretory pathways including inflammasome-related IL-1β secretion. TNFAIP8L2 (TIPE2) is a negative regulator of inflammasome. Together these suggest an inflammasome/oxidative stress program.
Genes
ABI3, ADISSP, AKR1A1, ARHGDIB, ARPC1B, ASCL2, BLVRA, C1orf54, CHCHD10, DNPH1, ERP29, FUOM, GIMAP1, GIMAP7, GSTK1, GSTM4, IGSF6, IMPA2, JPT1, LST1, LY86, MGST2, MIF4GD, MSRB2, NAGK, NDUFA3, NME4, NUBP1, NUCB2, PCBD1, PEBP1, PMVK, PRDX2, PTMS, PYCARD, RFC2, RGS10, TMEM176A, TMEM97, TNFAIP8L2, UCP2, VAMP8
Most correlated modules
- Mitochondrial OXPHOS · correlation 0.87
- Efferocytosis Anti-inflammatory · correlation 0.76
- MHC-II Antigen Presentation · correlation 0.68
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.