SCUBA

ABI3 — ABI family member 3

ABI3 belongs to a gene co-expression module in 9 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

ABI3's module in each cell type

Cell typeModuleShares the module with
CD4⁺ T cellsEffector Immune Activation
Immune regulation
APBB1IP, ASB2, BUB3, CALCOCO2, CASP4, COMMD7, CTSD, CXCR6 +7 moreView in SCUBA
CD8⁺ T cellsTc17 program
Tc17 program
ABRACL, CAPG, CCDC85B, FKBP11, GPR34, IL17A, KLRB1, NFKBIA +4 moreView in SCUBA
EndothelialVenous Endothelial Identity
Endothelial cell development
CCDC85B, DOCK4, EHD4, EVA1B, EXOC3L2, HDAC7, ITGA6, MCF2L +8 moreView in SCUBA
Gamma-delta T cellsLysosomal Biogenesis
Protein processing & ER
APLP2, ATP10A, B3GALT4, BAX, CD63, CTNNA1, DOCK5, EML2 +14 more
MacrophagesInflammasome Oxidative Stress
Inflammatory
ADISSP, AKR1A1, ARHGDIB, ARPC1B, ASCL2, BLVRA, C1orf54, CHCHD10 +33 moreView in SCUBA
MonocytesNon-classical Monocyte
Lysosomal & pahgocytosis
CAMK1, CD300A, CHCHD10, DAPK1, FCGR3A, GNGT2, ICAM2, ITM2B +5 moreView in SCUBA
Mucosal-associated invariant T cellCellular Housekeeping
Housekeeping
AP2M1, CD151, CD2, CKLF, DYNLL1, FDFT1, LRP10, NOP10 +7 more
Natural Killer cellsNK Cytotoxic Activation
Cytotoxicity
ALOX5AP, ARHGDIB, BPGM, CD247, GNPTAB, GZMA, HCLS1, LAT2 +3 moreView in SCUBA
PericytesVascular Permeability
Migration & adhesion
FLT1, GALNT18, ITGA6, NQO1, PLVAP, PRKCH, TM4SF18View in SCUBA

About the gene

SynonymsNESH, SSH3BP3
Chromosome17: 49210411-49223225
Predicted locationIntracellular
Essential geneNo
Protein classPredicted intracellular proteins

Function

May inhibit tumor metastasis (By similarity). In vitro, reduces cell motility

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.