AKR1A1 — Aldo-keto reductase family 1 member A1
AKR1A1 belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
AKR1A1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Lysosomal Autophagy Program Stress | ABCD4, ASPH, CD63, CFI, EBP, GNS, MAP1LC3A, MDH1 +4 more | View in SCUBA |
| Enterocytes | Enterocyte Ion/Nutrient Transport Absorption | AKR7A3, CALM1, CHP2, CLDN15, FCGRT, LGALS2, MGAT4B, MPST +2 more | View in SCUBA |
| Innate lymphoid cells | mTOR Metabolic Stress Stress | ADPGK, ATP5IF1, BAX, CPNE1, GLO1, GSTO1, HNRNPR, JAGN1 +9 more | View in SCUBA |
| Macrophages | Inflammasome Oxidative Stress Inflammatory | ABI3, ADISSP, ARHGDIB, ARPC1B, ASCL2, BLVRA, C1orf54, CHCHD10 +33 more | View in SCUBA |
| Monocytes | Monocyte Lipid Handling Lysosomal & pahgocytosis | CD81, FUOM, ISOC2, LAIR1, NPC2, RGL1, SIGLEC1, SPATS2L +1 more | View in SCUBA |
About the gene
| Synonyms | ALR, DD3 |
|---|---|
| Chromosome | 1: 45550543-45570049 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins |
| Molecular function | Oxidoreductase |
| Biological process | Lipid metabolism |
Function
Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols. Displays enzymatic activity towards endogenous metabolites such as aromatic and aliphatic aldehydes, ketones, monosaccharides and bile acids, with a preference for negatively charged substrates, such as glucuronate and succinic semialdehyde. Functions as a detoxifiying enzyme by reducing a range of toxic aldehydes (By similarity). Reduces methylglyoxal and 3-deoxyglucosone, which are present at elevated levels under hyperglycemic conditions and are cytotoxic (By similarity). Involved also in the detoxification of lipid-derived aldehydes like acrolein (By similarity). Plays a role in the activation of procarcinogens, such as polycyclic aromatic hydrocarbon trans-dihydrodiols, and in the metabolism of various xenobiotics and drugs, including the anthracyclines doxorubicin (DOX) and daunorubicin (DAUN). Also acts as an inhibitor of protein S-nitrosylation by mediating degradation of S-nitroso-coenzyme A (S-nitroso-CoA), a cofactor required to S- nitrosylate proteins. S-nitroso-CoA reductase activity is involved in reprogramming intermediary metabolism in renal proximal tubules, notably by inhibiting protein S-nitrosylation of isoform 2 of PKM (PKM2) (By similarity). Also acts as a S-nitroso- glutathione reductase by catalyzing the NADPH-dependent reduction of S- nitrosoglutathione. Displays no reductase activity towards retinoids (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.