ARPC1B — Actin related protein 2/3 complex subunit 1B

ARPC1B belongs to a gene co-expression module in 12 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

ARPC1B's module in each cell type

Cell type	Module	Shares the module with
CD19⁺ B cells	Actin Cytoskeleton Cytoskeletal	ACTB, ACTG1, ACTR3, ARPC2, ARPC4, ARPC5, BRK1, CAP1 +14 more	View in SCUBA
CD4⁺ T cells	Proteostasis OxPhos Housekeeping	AIP, ATP6V1F, C4orf48, CHMP2A, IL2RG, NDUFA13, NDUFB10, PPP1R7 +6 more	View in SCUBA
CD8⁺ T cells	Actin Cytoskeleton Cytoskeletal	ACTB, ARF6, ARPC4, BRK1, CAPZB, CFL1, CORO1A, FKBP1A +10 more	View in SCUBA
Endothelial	Mitochondrial OxPhos Mitochondrial & OxPhos	ATP5MF, AURKAIP1, NDUFB2, NDUFS6, PARVB, PFN1, POLR2E, SERF2 +3 more	View in SCUBA
Fibroblasts	Lysosomal Stress Response Stress	ATP6V0B, CTSB, FAM20C, GSTO1, IKBIP, MIF, PDLIM4, PKM +3 more	View in SCUBA
Gamma-delta T cells	Oxidative Phosphorylation Mitochondrial & OxPhos	ARPC4, ATP6V1F, COPE, COX6A1, COX6B1, COX6C, CSNK2B, NDUFA1 +12 more
Glial cells	Glial Identity Homeostasis Housekeeping	CMTM5, CPQ, DDAH2, FCGRT, METRN, PON2, S100B, SLC22A17 +2 more	View in SCUBA
Innate lymphoid cells	Mitochondrial OxPhos Mitochondrial & OxPhos	AKR7A2, ANXA6, AP2M1, ARL6IP4, ATP5MC2, ATP5PB, BSG, CCNDBP1 +21 more	View in SCUBA
Macrophages	Inflammasome Oxidative Stress Inflammatory	ABI3, ADISSP, AKR1A1, ARHGDIB, ASCL2, BLVRA, C1orf54, CHCHD10 +33 more	View in SCUBA
Mucosal-associated invariant T cell	T cell Identity T cell maturation	BLOC1S1, C4orf3, CD3D, CHKB, CPNE1, DDX39B, HMGN3, MARCHF9 +9 more
Natural Killer cells	Actin Cytoskeleton Remodeling Cytoskeleton & motility	ANXA6, ARPC4, BAX, CAPNS1, CAPZB, GNAI2, IL2RG, NDUFA13 +7 more	View in SCUBA
Smooth muscle cells	Vascular Matrix Secretion ECM remodeling	BGN, CALHM2, HSPB7, MGP, MXI1, RAB13, TRIM47	View in SCUBA

About the gene

Synonyms	ARC41, p40-ARC, p41-ARC
Chromosome	7: 99374249-99394816
Predicted location	Intracellular
Essential gene	No
Protein class	Disease related genes, Plasma proteins, Predicted intracellular proteins
Molecular function	Actin-binding

Function

Component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA. The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double- strand breaks (DSBs).

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.