BLVRA — Biliverdin reductase A
BLVRA belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
BLVRA's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Innate lymphoid cells | ILC Identity Program Differentiation | AHR, APOL4, ARHGEF12, CD300LF, CDK2AP2, CEP83, COL4A4, DERL1 +29 more | View in SCUBA |
| Macrophages | Inflammasome Oxidative Stress Inflammatory | ABI3, ADISSP, AKR1A1, ARHGDIB, ARPC1B, ASCL2, C1orf54, CHCHD10 +33 more | View in SCUBA |
| Monocytes | IFN-gamma Monocyte Activation Inflammatory | CYB5A, DRAP1, FCGR1A, GAS6, HLA-F, IFITM3, LGALS9, LILRB1 +3 more | View in SCUBA |
About the gene
| Synonyms | BLVR |
|---|---|
| Chromosome | 7: 43758680-43807342 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins |
| Molecular function | Oxidoreductase |
Function
Reduces the gamma-methene bridge of the open tetrapyrrole, biliverdin IXalpha, to bilirubin with the concomitant oxidation of a NADH or NADPH cofactor. Does not reduce bilirubin IXbeta. Uses the reactants NADH or NADPH depending on the pH; NADH is used at the acidic pH range (6-6.9) and NADPH at the alkaline range (8.5-8.7). NADPH, however, is the probable reactant in biological systems.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.