NUBP2 — NUBP iron-sulfur cluster assembly factor 2, cytosolic
NUBP2 belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
NUBP2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Innate lymphoid cells | Lipid & Isoprenoid Metabolism Metabolism | ARL6IP1, CHCHD5, ECH1, FDPS, GTF2H5, LYPLA1, NECAP2, OCIAD2 +8 more | View in SCUBA |
About the gene
| Synonyms | CFD1, CIAO6 |
|---|---|
| Chromosome | 16: 1782932-1789186 |
| Predicted location | Intracellular |
| Essential gene | Yes |
| Protein class | Essential proteins, Predicted intracellular proteins |
| Biological process | Cilium biogenesis/degradation |
Function
Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NUBP1-NUBP2 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins. Negatively regulates cilium formation and structure.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.