ECH1 — Enoyl-CoA hydratase 1

ECH1 belongs to a gene co-expression module in 8 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

ECH1's module in each cell type

Cell type	Module	Shares the module with
CD4⁺ T cells	Interferon-stimulated genes Anti-viral	APOBEC3G, ARPC4, ARPC5L, BAK1, BST2, DCTN3, ETFB, FAM104A +14 more	View in SCUBA
Gamma-delta T cells	DNA Repair Housekeeping Housekeeping	ANAPC16, CCDC85B, CDIP1, CKLF, COTL1, DNAJC4, ERCC1, IFT27 +10 more
Goblet cells	Oxidative Phosphorylation Mitochondrial & OxPhos	ATP5MG, ATP5PO, COX4I1, COX6A1, COX6C, COX7C, NDUFB5, UQCRB +1 more	View in SCUBA
Innate lymphoid cells	Lipid & Isoprenoid Metabolism Metabolism	ARL6IP1, CHCHD5, FDPS, GTF2H5, LYPLA1, NECAP2, NUBP2, OCIAD2 +8 more	View in SCUBA
Lymphatic endothelial	Fatty Acid Oxidation Lipid metabolism	ATRAID, ECHS1, ETFB, FCGRT, NDUFB10, PEBP1, PRDX2, TMEM14C	View in SCUBA
Macrophages	Mitochondrial OXPHOS Mitochondrial & OxPhos	ATP5IF1, ATP5MC2, FAM89B, GMFG, GSTP1, HIGD2A, LAMTOR4, NDUFA12 +9 more	View in SCUBA
Mucosal-associated invariant T cell	MAIT Tissue Residence Tissue residence	ANAPC16, ARHGDIB, ATP5IF1, CD3E, CD53, CD99, CTSD, CXCR6 +7 more
Natural Killer cells	NK Checkpoint Receptors Immune regulation	CD7, CD96, CRACR2B, DAPK2, ECI2, ISYNA1, KIR2DL4, MAP4 +5 more	View in SCUBA

About the gene

Synonyms	HPXEL
Chromosome	19: 38815422-38831841
Predicted location	Intracellular
Essential gene	No
Protein class	Metabolic proteins, Predicted intracellular proteins
Molecular function	Isomerase
Biological process	Fatty acid metabolism, Lipid metabolism

Function

Isomerization of 3-trans,5-cis-dienoyl-CoA to 2-trans,4- trans-dienoyl-CoA

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.