Lipid & Isoprenoid Metabolism
Gene co-expression module in Innate lymphoid cells
| Category | Metabolism |
|---|---|
| Genes | 17 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 7 of 17 genes have a known function matching the annotation |
Why this annotation
Hub genes FDPS (mevalonate/isoprenoid pathway), ECH1 (fatty acid oxidation), LYPLA1 (lysophospholipase), UQCC2 (mitochondrial respiratory chain assembly), and TIMM13 (mitochondrial protein import) collectively point to lipid and isoprenoid metabolism with mitochondrial support. FDPS is the rate-limiting enzyme in cholesterol/prenylation biosynthesis; ECH1 catalyzes FAO; LYPLA1 processes lysophospholipids. Moderate coherence and many weak memberships suggest a mixed lipid metabolic program. ILC1 enrichment is consistent across the batch.
Genes
ARL6IP1, CHCHD5, ECH1, FDPS, GTF2H5, LYPLA1, NECAP2, NUBP2, OCIAD2, POLD2, PRR13, RTF1, TIMM13, TMEM160, TSN, UFC1, UQCC2
Most correlated modules
- Mitochondrial Metabolism · correlation 0.97
- Glycolysis & OxPhos · correlation 0.96
- Mitochondrial OxPhos Biogenesis · correlation 0.95
- mTOR Metabolic Stress · correlation 0.95
- Proteasome & COPI Trafficking · correlation 0.95
- Oxidative Phosphorylation · correlation 0.94
- Proteasome & TCA · correlation 0.94
- RNA Processing & Proteostasis · correlation 0.94
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.