OGG1 — 8-oxoguanine DNA glycosylase
OGG1 belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
OGG1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | Somatic Hypermutation B cell maturation | DEF8, EAF2, HMCES, KLHL6, LBR, PHF6, PRPSAP2, RFC1 +3 more | View in SCUBA |
About the gene
| Synonyms | HMMH, HOGG1, MUTM, OGH1 |
|---|---|
| Chromosome | 3: 9749944-9788219 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Cancer-related genes, Disease related genes, Enzymes, Human disease related genes, Plasma proteins, Potential drug targets, Predicted intracellular proteins |
| Molecular function | Glycosidase, Hydrolase, Lyase, Multifunctional enzyme |
| Biological process | DNA damage, DNA repair |
Function
DNA repair enzyme that incises DNA at 8-oxoG residues. Excises 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-N- methylformamidopyrimidine (FAPY) from damaged DNA. Has a beta-lyase activity that nicks DNA 3' to the lesion
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.