DEF8 — Differentially expressed in FDCP 8 homolog
DEF8 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
DEF8's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | Somatic Hypermutation B cell maturation | EAF2, HMCES, KLHL6, LBR, OGG1, PHF6, PRPSAP2, RFC1 +3 more | View in SCUBA |
| Macrophages | ER Protein Translocation Vesicular traficking | ACADVL, ARRB2, BCL7B, BORCS7, DDRGK1, DNAJB12, DVL3, ELOVL1 +22 more | View in SCUBA |
About the gene
| Synonyms | FLJ20186 |
|---|---|
| Chromosome | 16: 89948697-89968060 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
Function
Positively regulates lysosome peripheral distribution and ruffled border formation in osteoclasts. Involved in bone resorption
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.