RFC1 — Replication factor C subunit 1

RFC1 belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

RFC1's module in each cell type

Cell type	Module	Shares the module with
CD19⁺ B cells	Somatic Hypermutation B cell maturation	DEF8, EAF2, HMCES, KLHL6, LBR, OGG1, PHF6, PRPSAP2 +3 more	View in SCUBA
Gamma-delta T cells	Chromatin Architecture DNA/chromatin regulation	CBFB, CCDC137, CTCF, DCAF15, GMCL1, HNRNPUL2, HP1BP3, KDM4A +9 more
Innate lymphoid cells	NK JAK3 Signaling activation	ANKRD44, APLP2, ATP8B4, CALCOCO2, ERLEC1, FLOT1, FUT8, FYCO1 +10 more	View in SCUBA
Lymphatic endothelial	Lymphatic Specification endothelial development	ARHGAP29, BOD1L1, CALD1, CLCN3, DECR1, GCC2, MINDY2, MPHOSPH8 +9 more	View in SCUBA
Macrophages	DNA Replication Metabolism Cell cycle	AGPAT5, CBX1, DCK, FADS1, HACD3, HADH, ICMT, IDH2 +11 more	View in SCUBA

About the gene

Synonyms	A1, MHCBFB, PO-GA, RFC140
Chromosome	4: 39287456-39366375
Predicted location	Intracellular
Essential gene	Yes
Protein class	Disease related genes, Essential proteins, Human disease related genes, Plasma proteins, Predicted intracellular proteins
Molecular function	Activator, DNA-binding
Biological process	DNA replication, Transcription, Transcription regulation

Function

Subunit of the replication factor C (RFC) complex which acts during elongation of primed DNA templates by DNA polymerases delta and epsilon, and is necessary for ATP-dependent loading of proliferating cell nuclear antigen (PCNA) onto primed DNA. This subunit binds to the primer-template junction. Binds the PO-B transcription element as well as other GA rich DNA sequences. Can bind single- or double-stranded DNA.

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.