PCSK2 — Proprotein convertase subtilisin/kexin type 2
PCSK2 belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
PCSK2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Glial cells | Glial ECM Scaffold ECM remodeling | CADM1, COL9A3, FBLN2, FGL2, ISLR, ITIH5, LTBP4, MAMDC2 +1 more | View in SCUBA |
About the gene
| Synonyms | NEC2, PC2, SPC2 |
|---|---|
| Chromosome | 20: 17226107-17484578 |
| Predicted location | Intracellular, Secreted |
| Essential gene | No |
| Protein class | Enzymes, Predicted intracellular proteins, Predicted secreted proteins |
| Molecular function | Hydrolase, Protease, Serine protease |
Function
Serine endopeptidase which is involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues. Responsible for the release of glucagon from proglucagon in pancreatic A cells.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.