Glial ECM Scaffold
Gene co-expression module in Glial cells
| Category | ECM remodeling |
|---|---|
| Genes | 10 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 9 of 10 genes have a known function matching the annotation |
Why this annotation
FBLN2 (fibulin-2) is an ECM glycoprotein expressed in basement membranes and connective tissue. MAMDC2 is an ECM protein with MAM and discoidin domains. COL9A3 is a fibrillar collagen subunit. ISLR (immunoglobulin superfamily leucine-rich repeat) is an ECM receptor. ITIH5 is an inter-alpha-trypsin inhibitor involved in hyaluronan-ECM stabilization. LTBP4 is a latent TGF-β binding protein. CADM1 is a synaptic cell adhesion molecule also expressed in glia. SLITRK6 is a synaptic organizer. FGL2 is a fibrinogen-like protein. PCSK2 is a proprotein convertase expressed in neural/endocrine cells. The module is strongly downregulated in both UC and CD inflammation and recovers in remission, consistent with loss of homeostatic glial ECM scaffolding. The ECM proteins (FBLN2, MAMDC2, COL9A3, ISLR, ITIH5, LTBP4) are the dominant theme, distinguishing this from M68 which features matricellular proteins.
Genes
CADM1, COL9A3, FBLN2, FGL2, ISLR, ITIH5, LTBP4, MAMDC2, PCSK2, SLITRK6
Most correlated modules
- Enteric Glial Identity · correlation 0.90
- Myelinating Schwann Cell · correlation 0.83
- Collagen ECM Deposition · correlation 0.80
- Peripheral Glial Myelination · correlation 0.77
- Matricellular ECM Homeostasis · correlation 0.76
- ECM Homeostatic Regulation · correlation 0.76
- Neuroprotective Secretory · correlation 0.73
- Glial Synaptic Adhesion · correlation 0.71
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.