LTBP4 — Latent transforming growth factor beta binding protein 4
LTBP4 belongs to a gene co-expression module in 6 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
LTBP4's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Arterial EC Identity Endothelial cell development | AFAP1L2, BMP4, CFAP36, FUT8, ITPR2, JAG1, NEBL, NPTXR +6 more | View in SCUBA |
| Fibroblasts | Subepithelial Fibroblast Developmental | A2M, ABCA10, ABCA6, ABCA8, ABCA9, ADAMDEC1, CFD, CTSC +8 more | View in SCUBA |
| Glial cells | Glial ECM Scaffold ECM remodeling | CADM1, COL9A3, FBLN2, FGL2, ISLR, ITIH5, MAMDC2, PCSK2 +1 more | View in SCUBA |
| Lymphatic endothelial | ECM Remodeling TGFb migration & adhesion | CCDC80, CCND1, CHRDL1, CRIP1, CTSH, ECSCR, HS3ST1, IARS2 +8 more | View in SCUBA |
| Pericytes | Pericyte Identity Developmental | ADAMDEC1, EDIL3, EMID1, FOXF1, IL1R1, LRP1, MXRA5, NR2F1 +2 more | View in SCUBA |
| Smooth muscle cells | Fibroblast Matrisome ECM remodeling | ADAMDEC1, EMP1, FBLN1, NR2F1, PLTP, PROCR, RGS10, S100A10 +1 more | View in SCUBA |
About the gene
| Synonyms | FLJ46318, FLJ90018, LTBP-4, LTBP-4L |
|---|---|
| Chromosome | 19: 40592883-40629818 |
| Predicted location | Intracellular, Secreted |
| Essential gene | No |
| Protein class | Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins |
| Molecular function | Growth factor binding |
Function
Key regulator of transforming growth factor beta (TGFB1, TGFB2 and TGFB3) that controls TGF-beta activation by maintaining it in a latent state during storage in extracellular space. Associates specifically via disulfide bonds with the Latency-associated peptide (LAP), which is the regulatory chain of TGF-beta, and regulates integrin-dependent activation of TGF-beta
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.